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李冬

作者:   时间:2026-11-11   点击数:

职称:副教授

是否具有招生资格:是导师类型:硕士研究生导师

研究生招生方向:生物学、微生物学

学习经历、社会兼职及获奖情况

201009-201407赤峰学院 生物技术 理学学士(本科)

201409-201707塔里木大学 生物化学与分子生物学 理学硕士(研究生)

201809-202301江南大学 发酵工程 工学博士 (研究生)

202301-202502江南大学 食品科学学院 博士后

202507-今 宁夏大学 生命科学学院 硕士研究生导师

主要从事微生物代谢工程、合成生物学、酶工程和绿色生物制造研究,重点开展维生素C前体2-酮基-L-古龙酸绿色生物合成、关键酶催化机制与分子改造、工业微生物底盘细胞构建,以及宁夏特色微生物资源挖掘、利用和种质资源库建设。近年来主持国家自然科学基金青年项目、宁夏自然科学基金项目、国家资助博士后研究人员计划和江苏省卓越博士后计划等科研项目,参与国家重点研发计划、国家自然科学基金重点项目和创新研究群体项目。以第一作者或通讯作者在Advanced Science等期刊发表SCI论文7篇,授权国家发明专利3项,登记宁夏回族自治区科学技术成果1项。荣获宁夏回族自治区科学技术奖自然科学奖二等奖(6/6)。兼任《宁夏大学学报(自然科学版中英文)》青年编委。

获奖情况:

2023年江苏省卓越博士后计划、2023年度国家资助博士后研究人员计划B档

研究领域

1)微生物代谢工程和合成生物学强化微生物高效合成高值产品相关研究;

2)宁夏特色微生物挖掘、利用和种质资源库的构建。

代表性研究成果

(1)Li D, Deng ZW, Hou XD, et al. Structural Insight into the Catalytic Mechanisms of an L-Sorbosone Dehydrogenase. Advanced Science, 2023, 10(30): e2301955.(SCI一区TOP,影响因子:14.3)

(2)Wang F, Zhou Q, Wang YP, Wang ZW,Li D*. Sustainable 2-Keto-L-Gulonic Acid Biosynthesis via Single-Strain One-Step Fermentation. Applied and Environmental Microbiology, 2026: e01631-26. DOI: 10.1128/aem.01631-26.(SCI二区,影响因子:4.2)

(3)Li D, Fan JX, Zong JF, et al. Sustainable production of natural sweeteners through synthetic biology. Journal of Bioscience and Bioengineering, 2026, 142(2): 109–121.(SCI,影响因子:2.5)

(4)Li D, Wang XL, Qin ZJ, et al. Combined engineering of L-sorbose dehydrogenase and fermentation optimization to increase 2-keto-L-gulonic acid production in Escherichia coli. Bioresource Technology, 2023, 372: 128672.(SCI一区TOP,影响因子:9.7)

(3)Li D, Liu L, Qin ZJ, et al. Combined evolutionary and metabolic engineering improve 2-keto-L-gulonic acid production in Gluconobacter oxydans WSH-004. Bioresource Technology, 2022, 354: 127107.(SCI一区TOP,影响因子:11.4)

(6)Li D, Wang XL, Huo L, et al. Computer-Aided Semi-Rational Design to Enhance the Activity of L-Sorbosone Dehydrogenase from Gluconobacter oxydans WSH-004. Journal of Agricultural and Food Chemistry, 2024, 72(19): 10995–11001.(SCI一区TOP,影响因子:6.2)

(7)Li D, Huo L, Jiang S, et al. Insights into the mechanism underlying the formation of covalent dimers of glucose/sorbosone dehydrogenase. Food Bioscience, 2024, 62: 105199.(SCI一区TOP,影响因子:5.9)

(8) Wang XY, Qin ZJ,Li D, et al. Multi-dimensional protein engineering and coupled network optimization enable high-titer 2-KLG green biosynthesis in Gluconobacter oxydans. Chemical Engineering Journal, 2026.(SCI一区TOP,影响因子:12.5)

(9) Mou FM,Li D, et al. Directed evolution of heme biosynthetic enzymes enabled by a growth-coupled heme biosensor in Corynebacterium glutamicum. Synthetic and Systems Biotechnology, 2026.(SCI一区TOP,影响因子:4.8)

(10) Wang XR, Wang L, Chen QH,Li D, et al. Efficient production of hydroxysalidroside in Escherichia coli via enhanced glycosylation and semi-rational design of UGT85A1. Synthetic and Systems Biotechnology, 2025.(SCI一区TOP,影响因子:4.8)

(11) Wang XY,Li D, Qin ZJ, et al. Anti-CRISPR proteins in Gluconobacter oxydans inactivate FnCas12a by acetylation. International Journal of Biological Macromolecules, 2025.(SCI一区TOP,影响因子:8.7)

(12) Gao S, Zeng WZ,Li D, et al. Efficient Biosynthesis of 8-Prenylkaempferol from Kaempferol by Using Flavonoid 8-Dimethylallyltransferase Derived from Epimedium koreanum. Journal of Agricultural and Food Chemistry, 2025.(SCI一区TOP,影响因子:6.7)

(13) Wang L, Chen QH,Li D, et al. Improving Production of Coniferyl Alcohol in Escherichia coli by Regulating the Multiple Cofactors and Efflux of Intermediates. ACS Sustainable Chemistry & Engineering, 2024.(SCI一区TOP,影响因子:7.3)

(14) Wu R,Li D, Chen Q, et al. Optimization of vanillin biosynthesis in Escherichia coli K12 MG1655 through metabolic engineering. Bioresource Technology, 2024, 411: 131189.(SCI一区TOP,影响因子:9.0)

(15) Liu S,Li D, Zhao X, et al. Production of food flavor and color by synthetic biology. Current Opinion in Food Science, 2024: 101168.(SCI一区TOP,影响因子:9.1)

(16) Zeng WZ,Li D, Zhang HH, et al. Multi-strategy integration improves 28-O-glucosylation of asiatic acid into asiatic acid monoglucoside. Food Bioscience, 2024, 61.(SCI一区TOP,影响因子:5.9)

(17) Wang XY,Li D, Qin ZJ, et al. CRISPR/Cpf1–FOKI-induced gene editing in Gluconobacter oxydans. Synthetic and Systems Biotechnology, 2024, 9(2): 369–379.(SCI一区TOP,影响因子:4.4)

(18) Li G,Li D, Zeng WZ, et al. Efficient production of 2-keto-L-gulonic acid from D-glucose in Gluconobacter oxydans ATCC 9937 by mining key enzyme and transporter. Bioresource Technology, 2023, 384: 129316.(SCI一区TOP,影响因子:9.7)

(19) Liu SK,Li D, Qin ZJ, et al. Enhancing Glycosylation of Flavonoids by Engineering the Uridine Diphosphate Glucose Supply in Escherichia coli. Journal of Agricultural and Food Chemistry, 2023, 71(46): 17842–17851.(SCI一区TOP,影响因子:5.7)

(20) Zhang Q, Wang XL, Zeng WZ,Li D, et al. De novo biosynthesis of carminic acid in Saccharomyces cerevisiae. Metabolic Engineering, 2023, 76: 50–62.(SCI一区TOP,影响因子:6.8)

(21) Qin ZJ, Wang XL, Gao S,Li D, et al. Production of Natural Pigments Using Microorganisms. Journal of Agricultural and Food Chemistry, 2023.(SCI一区TOP,影响因子:5.7)

(22) Chen Y,Li D, Shan XY, et al. Characterization of a sorbose oxidase involved in the biosynthesis of 2-keto-L-gulonic acid from Gluconobacter oxydans WSH-004. Process Biochemistry, 2022, 116: 1–7.(SCI三区,影响因子:4.4)

(23)Li D, Chen ZJ, Luo XX, Xia ZF, Wan CX, Zhang LL. Saccharomonospora xiaoerkulensis sp. nov., isolated from lake sediment. International Journal of Systematic and Evolutionary Microbiology, 2016, 66(12): 5145–5149.(SCI,影响因子:2.1)

(24)可提升2-KLG产量的L-山梨糖脱氢酶突变体,国家发明专利,ZL202210756716.9。

(25) L-山梨糖脱氢酶突变体及其应用,国家发明专利,ZL202210784572.8。

(26)催化活性提高的L-山梨酮脱氢酶突变体,国家发明专利,ZL202111420059.2。

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